Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis

PURPOSE: This study aimed to quantify the probability of overdiagnosis of prostate cancer by polygenic risk. Genet Med 17 10, 789–795. METHODS: We calculated the polygenic risk score based on 66 known prostate cancer susceptibility variants for 17,012 men aged 50–69 years (9,404 men identified with...

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Vydáno v:Genet Med
Hlavní autoři: Pashayan, Nora, Duffy, Stephen W., Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Martin, Richard M., Harrington, Patricia, Benlloch, Sara, Amin Al Olama, Ali, Shah, Mitul, Kote-Jarai, Zsofia, Easton, Douglas F., Eeles, Rosalind, Pharoah, Paul D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430305/
https://ncbi.nlm.nih.gov/pubmed/25569441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2014.192
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