Reducing overdiagnosis by polygenic risk-stratified screening: findings from the Finnish section of the ERSPC

BACKGROUND: We derived estimates of overdiagnosis by polygenic risk groups and examined whether polygenic risk-stratified screening for prostate cancer reduces overdiagnosis. METHODS: We calculated the polygenic risk score based on genotypes of 66 known prostate cancer loci for 4967 men from the Fin...

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Dettagli Bibliografici
Pubblicato in:Br J Cancer
Autori principali: Pashayan, Nora, Pharoah, Paul DP, Schleutker, Johanna, Talala, Kirsi, Tammela, Teuvo LJ, Määttänen, Liisa, Harrington, Patricia, Tyrer, Jonathan, Eeles, Rosalind, Duffy, Stephen W, Auvinen, Anssi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
Soggetti:
Epidemiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651137/
https://ncbi.nlm.nih.gov/pubmed/26291059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.289
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