Polygenic susceptibility to prostate and breast cancer: implications for personalised screening

BACKGROUND: We modelled the efficiency of a personalised approach to screening for prostate and breast cancer based on age and polygenic risk-profile compared with the standard approach based on age alone. METHODS: We compared the number of cases potentially detectable by screening in a population u...

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Bibliographic Details
Main Authors: Pashayan, N, Duffy, S W, Chowdhury, S, Dent, T, Burton, H, Neal, D E, Easton, D F, Eeles, R, Pharoah, P
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
Subjects:
Genetics and Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093360/
https://ncbi.nlm.nih.gov/pubmed/21468051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.118
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