Parathyroid hormone decreases HCO3 reabsorption in the rat proximal tubule by stimulating phosphatidylinositol metabolism and inhibiting base exit.

The mechanism of inhibition of HCO3 transport by parathyroid hormone (PTH) in the proximal tubule is not clearly defined. Previous studies in vitro have suggested that this effect is mediated via cAMP generation, which acts to inhibit Na/H exchange, resulting in cell acidification. To examine this q...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Pastoriza-Munoz, E, Harrington, R M, Graber, M L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443019/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1314850/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115739
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