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Up-regulation of the Hippo pathway effector TAZ renders lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to gefitinib

BACKGROUND: The T790M mutation of epithelial growth factor receptor (EGFR) is a major cause of the acquired resistance to EGFR tyrosine kinase inhibitor (EGFR-TKIs) treatment for lung cancer patients. The Hippo pathway effector, TAZ, has emerged as a key player in organ growth and tumorigenesis, inc...

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書目詳細資料
發表在:Cell Biosci
Main Authors: Xu, Wei, Wei, Yunyan, Wu, Shuangshuang, Wang, Yun, Wang, Zhen, Sun, Yu, Cheng, Steven Y, Wu, Jianqing
格式: Artigo
語言:Inglês
出版: BioMed Central 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429831/
https://ncbi.nlm.nih.gov/pubmed/25973173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3701-5-7
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