Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.

The p53 gene was examined in primary lymphoblasts of 25 pediatric patients with acute lymphoblastic leukemia by the RNase protection assay and by single strand conformation polymorphism analysis in 23 of 25 cases. p53 mutations were found to occur, but at a low frequency (4 of 25). While all four mu...

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Hlavní autoři: Felix, C A, Nau, M M, Takahashi, T, Mitsudomi, T, Chiba, I, Poplack, D G, Reaman, G H, Cole, D E, Letterio, J J, Whang-Peng, J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC442897/
https://ncbi.nlm.nih.gov/pubmed/1737852
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