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Optimization of Translation Profiles Enhances Protein Expression and Solubility
mRNA is translated with a non-uniform speed that actively coordinates co-translational folding of protein domains. Using structure-based homology we identified the structural domains in epoxide hydrolases (EHs) and introduced slow-translating codons to delineate the translation of single domains. Th...
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| Udgivet i: | PLoS One |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4428881/ https://ncbi.nlm.nih.gov/pubmed/25965266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127039 |
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