Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

The anti-invasive and anti-proliferative effects of betulins and abietane derivatives was systematically tested using an organotypic model system of advanced, castration-resistant prostate cancers. A preliminary screen of the initial set of 93 compounds was performed in two-dimensional (2D) growth c...

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Publicado en:PLoS One
Autores principales: Härmä, Ville, Haavikko, Raisa, Virtanen, Johannes, Ahonen, Ilmari, Schukov, Hannu-Pekka, Alakurtti, Sami, Purev, Enkhee, Rischer, Heiko, Yli-Kauhaluoma, Jari, Moreira, Vânia M., Nees, Matthias, Oksman-Caldentey, Kirsi-Marja
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428838/
https://ncbi.nlm.nih.gov/pubmed/25965345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126111
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