Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small inc...

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Main Authors: Jawien, A, Bowen-Pope, D F, Lindner, V, Schwartz, S M, Clowes, A W
Formato: Artigo
Idioma:Inglês
Publicado: 1992
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC442880/
https://ncbi.nlm.nih.gov/pubmed/1531345
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