Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small inc...

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Pubblicato in:	J Clin Invest
Autori principali:	Jawien, A, Bowen-Pope, D F, Lindner, V, Schwartz, S M, Clowes, A W
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1531345/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115613
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