IL-10 producing intestinal macrophages prevent excessive anti-bacterial innate immunity by limiting IL-23 synthesis

Innate immune responses are regulated in the intestine to prevent excessive inflammation. Here we show that a subset of mouse colonic macrophages constitutively produce the anti-inflammatory cytokine IL-10. In mice infected with Citrobacter rodentium, a model for enteropathogenic Escherichia coli in...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Krause, Petra, Morris, Venetia, Greenbaum, Jason A., Park, Yoon, Bjoerheden, Unni, Mikulski, Zbigniew, Muffley, Tracy, Shui, Jr-Wen, Kim, Gisen, Cheroutre, Hilde, Liu, Yun- Cai, Peters, Bjoern, Kronenberg, Mitchell, Murai, Masako
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428691/
https://ncbi.nlm.nih.gov/pubmed/25959063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8055
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