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Sterically Stabilized Liposomes Incorporating the Novel Anticancer Agent Phospho-Ibuprofen (MDC-917): Preparation, Characterization, and In Vitro/In Vivo Evaluation

PURPOSE: To incorporate phospho-ibuprofen (P-I), a lipophilic, water insoluble novel anti-cancer agent, into pegylated liposomes and upon formulation optimization to evaluate its antitumor activity in vitro and in vivo. METHODS: P-I loaded liposomes were prepared using the thin-film hydration method...

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Détails bibliographiques
Publié dans:Pharm Res
Auteurs principaux: Mattheolabakis, George, Nie, Ting, Constantinides, Panayiotis P., Rigas, Basil
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428579/
https://ncbi.nlm.nih.gov/pubmed/22072052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0619-y
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