Myocyte-mediated Arginase Expression Controls Hyperargininemia but not Hyperammonemia in Arginase-deficient Mice

Human arginase deficiency is characterized by hyperargininemia and infrequent episodes of hyperammonemia that cause neurological impairment and growth retardation. We previously developed a neonatal mouse adeno-associated viral vector (AAV) rh10-mediated therapeutic approach with arginase expressed...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Hu, Chuhong, Kasten, Jennifer, Park, Hana, Bhargava, Ragini, Tai, Denise S, Grody, Wayne W, Nguyen, Quynh G, Hauschka, Stephen D, Cederbaum, Stephen D, Lipshutz, Gerald S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428413/
https://ncbi.nlm.nih.gov/pubmed/24888478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.99
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