Aminoglycosides Restore Full-length Type VII Collagen by Overcoming Premature Termination Codons: Therapeutic Implications for Dystrophic Epidermolysis Bullosa

Patients with recessive dystrophic epidermolysis bullosa (RDEB) have severe, incurable skin fragility, blistering, and multiple skin wounds due to mutations in the gene encoding type VII collagen (C7), the major component of anchoring fibrils mediating epidermal-dermal adherence. Nearly 10–25% of RD...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Ther
Päätekijät: Cogan, Jon, Weinstein, Jacqueline, Wang, Xinyi, Hou, Yingping, Martin, Sabrina, South, Andrew P, Woodley, David T, Chen, Mei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2014
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428404/
https://ncbi.nlm.nih.gov/pubmed/25155989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.140
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