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Non-apoptotic and extracellular activity of Granzyme B mediates resistance to Treg suppression by HLA-DR(neg)CD25(hi)CD127(lo) Tregs in multiple sclerosis and in response to IL-6
In autoimmune patients, regulatory T cells are increasingly found to be unable to suppress patient-derived T cells, an outcome referred to as Treg resistance. Here we show that CD4 T cells from patients with MS resist suppression by patient derived- or healthy donor derived- ex vivo Tregs. Important...
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| Publicado no: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4428169/ https://ncbi.nlm.nih.gov/pubmed/25637022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303257 |
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