Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro

BACKGROUND: EpCAM is highly expressed on membrane of epithelial tumor cells and has been detected as soluble/secreted (sEpCAM) in serum of cancer patients. In this study we established an ELISA for in vitro diagnostics to measure sEpCAM concentrations in ascites. Moreover, we evaluated the influence...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Seeber, Andreas, Martowicz, Agnieszka, Spizzo, Gilbert, Buratti, Thomas, Obrist, Peter, Fong, Dominic, Gastl, Guenther, Untergasser, Gerold
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427982/
https://ncbi.nlm.nih.gov/pubmed/25947366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1371-1
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