Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.

In inflammatory diseases such as rheumatoid arthritis, functions of chondrocytes including synthesis of matrix proteins and proteinases are altered through interactions with cells of the infiltrating pannus. One of the major secreted products of mononuclear inflammatory cells is IL-1. In this study...

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Publié dans:	J Clin Invest
Auteurs principaux:	Goldring, M B, Birkhead, J, Sandell, L J, Kimura, T, Krane, S M
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1988
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442785/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3264290/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113823
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