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Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization
Polymerization of the Z variant alpha-1-antitrypsin (Z-α1AT) results in the most common and severe form of α1AT deficiency (α1ATD), a debilitating genetic disorder whose clinical manifestations range from asymptomatic to fatal liver and/or lung disease. As the altered conformation of Z-α1AT and its...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4427445/ https://ncbi.nlm.nih.gov/pubmed/25961288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126256 |
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