High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy

Hyperglycemia was reported to cause bone marrow hematopoietic niche dysfunction, and high glucose (HG) in the cultured medium induces MSC senescence. The underlying mechanism is unclear. Here, we investigated the role of HG-induced autophagy in bone-marrow-derived mesenchymal stem cell (BMSC) senesc...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Chang, Tzu-Ching, Hsu, Min-Fen, Wu, Kenneth K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427318/
https://ncbi.nlm.nih.gov/pubmed/25961745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126537
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