Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats

Renal insufficiency can have a negative impact on cognitive function. Neuroinflammation and changes in klotho levels associate with chronic kidney disease (CKD) and may play a role in the development of cognitive impairment (CI). The present study evaluates the correlation of cognitive deficits with...

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Veröffentlicht in:PLoS One
Hauptverfasser: Degaspari, Sabrina, Tzanno-Martins, Carmen Branco, Fujihara, Clarice Kazue, Zatz, Roberto, Branco-Martins, João Paulo, Viel, Tania Araujo, Buck, Hudson de Souza, Orellana, Ana Maria Marques, Böhmer, Ana Elisa, de Sá Lima, Larissa, Andreotti, Diana Zukas, Munhoz, Carolina Demarchi, Scavone, Cristoforo, Kawamoto, Elisa Mitiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427267/
https://ncbi.nlm.nih.gov/pubmed/25961830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125271
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