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Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target
In prokaryotes, RNA derived from type I and type III CRISPR loci direct large ribonucleoprotein complexes to destroy invading bacteriophage and plasmids. In Escherichia coli, this 405-kDa complex is called Cascade. Here we report the 3.03Å crystal structure of Cascade bound to a single-stranded DNA...
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| Publicado no: | Science |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4427192/ https://ncbi.nlm.nih.gov/pubmed/25123481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1256996 |
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