Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor.

Activated protein C (APC) acts as a potent anticoagulant enzyme by inactivating Factor V and Factor VIII. In this study, protein S was shown to increase the inactivation of purified Factor VIII by APC ninefold. The reaction rate was saturated with respect to the concentration of protein S when prote...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Koedam, J A, Meijers, J C, Sixma, J J, Bouma, B N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442674/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2971673/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113721
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