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Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations

Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have side effects, as compared to those which have no re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Perez-Lopez, Áron R., Szalay, Kristóf Z., Türei, Dénes, Módos, Dezső, Lenti, Katalin, Korcsmáros, Tamás, Csermely, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426692/
https://ncbi.nlm.nih.gov/pubmed/25960144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10182
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