Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase

Streptosporangium sibiricum SibL catalyzes the methyl transfer from S-adenosylmethionine (SAM) to 3-hydroxykynurenine (3-HK) to produce S-adenosylhomocysteine (SAH) and 3-hydroxy-4-methyl-kynurenine for sibiromycin biosynthesis. Here, we present the crystal structures of apo-form Ss-SibL, Ss-SibL/SA...

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Publicado no:Sci Rep
Main Authors: Chen, Sheng-Chia, Huang, Chi-Hung, Lai, Shu-Jung, Liu, Jai-Shin, Fu, Pin-Kuei, Tseng, Shih-Ting, Yang, Chia Shin, Lai, Mei-Chin, Ko, Tzu-Ping, Chen, Yeh
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426599/
https://ncbi.nlm.nih.gov/pubmed/25960001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10100
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