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Premature termination of variable gene rearrangement in B lymphocytes from X-linked agammaglobulinemia.
X-linked agammaglobulinemia (XLA) results from failure of B lymphocyte development. Immature B cells from a patient with XLA were found to produce truncated mu and delta immunoglobulin H chains encoded by D-JH-C (mu delta). The 5' terminal sequence of cDNA encoding the H chains is composed of D...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1988
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC442655/ https://ncbi.nlm.nih.gov/pubmed/2838527 |
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