Synthesis of atrial natriuretic polypeptide in human failing hearts. Evidence for altered processing of atrial natriuretic polypeptide precursor and augmented synthesis of beta-human ANP.

To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, 20 human right auricles obtained at cardiovascular surgery were studied. The concentration of alpha-human ANP-like immunoreactivity (alpha-hANP-LI) in human right auricles ranged from 13.8 to 593.5 micrograms/g,...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Sugawara, A, Nakao, K, Morii, N, Yamada, T, Itoh, H, Shiono, S, Saito, Y, Mukoyama, M, Arai, H, Nishimura, K
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1988
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2968368/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113544
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