Synthesis of atrial natriuretic polypeptide in human failing hearts. Evidence for altered processing of atrial natriuretic polypeptide precursor and augmented synthesis of beta-human ANP.

To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, 20 human right auricles obtained at cardiovascular surgery were studied. The concentration of alpha-human ANP-like immunoreactivity (alpha-hANP-LI) in human right auricles ranged from 13.8 to 593.5 micrograms/g,...

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Bibliographic Details
Main Authors: Sugawara, A, Nakao, K, Morii, N, Yamada, T, Itoh, H, Shiono, S, Saito, Y, Mukoyama, M, Arai, H, Nishimura, K
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC442649/
https://ncbi.nlm.nih.gov/pubmed/2968368
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