An LXR–NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux

LXR–cofactor complexes activate the gene expression program responsible for cholesterol efflux in macrophages. Inflammation antagonizes this program, resulting in foam cell formation and atherosclerosis; however, the molecular mechanisms underlying this antagonism remain to be fully elucidated. We u...

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Bibliografische gegevens
Gepubliceerd in:EMBO J
Hoofdauteurs: Gillespie, Mark A, Gold, Elizabeth S, Ramsey, Stephen A, Podolsky, Irina, Aderem, Alan, Ranish, Jeffrey A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2015
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426483/
https://ncbi.nlm.nih.gov/pubmed/25755249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489819
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