Pathway-Based Factor Analysis of Gene Expression Data Produces Highly Heritable Phenotypes That Associate with Age

Statistical factor analysis methods have previously been used to remove noise components from high-dimensional data prior to genetic association mapping and, in a guided fashion, to summarize biologically relevant sources of variation. Here, we show how the derived factors summarizing pathway expres...

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Bibliographische Detailangaben
Veröffentlicht in:G3 (Bethesda)
Hauptverfasser: Anand Brown, Andrew, Ding, Zhihao, Viñuela, Ana, Glass, Dan, Parts, Leopold, Spector, Tim, Winn, John, Durbin, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2015
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Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426370/
https://ncbi.nlm.nih.gov/pubmed/25758824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.114.011411
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