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IL-13 desensitizes β2 adrenergic receptors in human airway epithelial cells through a 15-Lipoxygenase: G-protein receptor kinase 2 mechanism
BACKGROUND: Beta-2 adrenergic receptor (β2AR) agonists are critical treatments for asthma. However, receptor desensitization can lead to loss of therapeutic effects. While desensitization to repeated use of β2 agonists is well studied, Type-2 inflammation could also impact β2AR function. OBJECTIVE:...
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| Publicado no: | J Allergy Clin Immunol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4426258/ https://ncbi.nlm.nih.gov/pubmed/25819984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.02.006 |
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