Elastase regulates the synthesis of its inhibitor, alpha 1-proteinase inhibitor, and exaggerates the defect in homozygous PiZZ alpha 1 PI deficiency.

The net balance of neutrophil elastase, an enzyme that degrades many components of the extracellular matrix, and its inhibitor, alpha-1-proteinase inhibitor (alpha 1 PI), is thought to be a critical determinant in the development of destructive lung disease, especially in individuals with homozygous...

Description complète

Détails bibliographiques

Publié dans:	J Clin Invest
Auteurs principaux:	Perlmutter, D H, Travis, J, Punsal, P I
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1988
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442624/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3260245/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113519
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!