CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

Regulatory T cells (T(regs)) are key mediators of immune tolerance and feature prominently in cancer. Depletion of CD25(+) FoxP3(+) T(regs) in vivo may promote T cell cancer immunosurveillance, but no strategy to do so in humans while preserving immunity and preventing autoimmunity has been validate...

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Vydáno v:Sci Transl Med
Hlavní autoři: Rech, Andrew J., Mick, Rosemarie, Martin, Sunil, Recio, Adri, Aqui, Nicole A., Powell, Daniel J., Colligon, Theresa A., Trosko, Jennifer A., Leinbach, Leah I., Pletcher, Charles H., Tweed, Carol K., DeMichele, Angela, Fox, Kevin R., Domchek, Susan M., Riley, James L., Vonderheide, Robert H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425934/
https://ncbi.nlm.nih.gov/pubmed/22593175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003330
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