Treatment of established left ventricular hypertrophy with fibroblast growth factor receptor blockade in an animal model of CKD

BACKGROUND: Activation of fibroblast growth factor receptor (FGFR)-dependent signalling by FGF23 may contribute to the complex pathogenesis of left ventricular hypertrophy (LVH) in chronic kidney disease (CKD). Pan FGFR blockade by PD173074 prevented development of LVH in the 5/6 nephrectomy rat mod...

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Bibliografiske detaljer
Udgivet i:Nephrol Dial Transplant
Main Authors: Di Marco, Giovana Seno, Reuter, Stefan, Kentrup, Dominik, Grabner, Alexander, Amaral, Ansel Philip, Fobker, Manfred, Stypmann, Jörg, Pavenstädt, Hermann, Wolf, Myles, Faul, Christian, Brand, Marcus
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425841/
https://ncbi.nlm.nih.gov/pubmed/24875663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfu190
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