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Leukaemic transformation by CALM–AF10 involves upregulation of Hoxa5 by hDOT1L

Chromosomal translocation is a common cause of leukaemia(1) and the most common chromosome translocations found in leukaemia patients involve the mixed lineage leukaemia (MLL) gene(2,3). AF10 is one of more than 30 MLL fusion partners in leukaemia(4). We have recently demonstrated that the H3K79 met...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Okada, Yuki, Jiang, Qi, Lemieux, Margot, Jeannotte, Lucie, Su, Lishan, Zhang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425349/
https://ncbi.nlm.nih.gov/pubmed/16921363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1464
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