CD40 dependent exacerbation of immune mediated hepatitis by hepatic CD11b(+) Gr-1(+) myeloid derived suppressor cells in tumor bearing mice

Immunosuppressive CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSC) accumulate in the livers of tumor-bearing mice. We studied hepatic MDSC in two murine models of immune mediated hepatitis. Unexpectedly, treatment of tumor bearing mice with Concanavalin A or α-Galactosylceramide resulted in i...

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Bibliographic Details
Published in:Eur J Immunol
Main Authors: Kapanadze, Tamar, Medina-Echeverz, José, Gamrekelashvili, Jaba, Weiss, Jonathan M., Wiltrout, Robert H., Kapoor, Veena, Hawk, Nga, Terabe, Masaki, Berzofsky, Jay A., Manns, Michael P., Wang, Ena, Marincola, Francesco M., Korangy, Firouzeh, Greten, Tim F.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425346/
https://ncbi.nlm.nih.gov/pubmed/25616156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201445093
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