IFN-γ regulates survival and function of tumor-induced CD11b(+)Gr-1(high) myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1

Myeloid derived suppressor cells (MDSCs) play a critical role in suppression of immune responses in cancer and inflammation. Here, we describe how regulation of Bcl2a1 by cytokines controls the suppressor function of CD11b(+)Gr-1(high) granulocytic MDSCs. Co-culture of CD11b(+)Gr-1(high) granulocyti...

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Main Authors: Medina-Echeverz, José, Haile, Lydia A., Zhao, Fei, Gamrekelashvili, Jaba, Ma, Chi, Métais, Jean-Yves, Dunbar, Cynthia E., Kapoor, Veena, Manns, Michael P., Korangy, Firouzeh, Greten, Tim F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140991/
https://ncbi.nlm.nih.gov/pubmed/24810636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201444497
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