Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel

During the long-term evolution of animal toxins acting on potassium channels, the acidic residues can orientate the toxin binding interfaces by adjusting the molecular polarity. Based on the evolutionary function of toxin acidic residues, de novo peptide drugs with distinct binding interfaces were d...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Chen, Zongyun, Hu, Youtian, Hong, Jing, Hu, Jun, Yang, Weishan, Xiang, Fang, Yang, Fan, Xie, Zili, Cao, Zhijian, Li, Wenxin, Lin, Donghai, Wu, Yingliang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424837/
https://ncbi.nlm.nih.gov/pubmed/25955787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09881
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