The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV-malaria co-treatment

BACKGROUND: HIV-malaria co-infected patients in most parts of sub-Saharan Africa are treated with both artemether-lumefantrine (AL) and efavirenz (EFV) or nevirapine (NVP)-based antiretroviral therapy (ART). EFV, NVP, artemether and lumefantrine are substrates, inhibitors or inducers of CYP3A4 and C...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Maganda, Betty A, Ngaimisi, Eliford, Kamuhabwa, Appolinary AR, Aklillu, Eleni, Minzi, Omary MS
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424554/
https://ncbi.nlm.nih.gov/pubmed/25906774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-0695-2
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