The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice

Skeletal integrity is maintained by the co-ordinated activity of osteoblasts, the bone-forming cells, and osteoclasts, the bone-resorbing cells. In this study, we show that mice overexpressing galectin-8, a secreted mammalian lectin of the galectins family, exhibit accelerated osteoclasts activity a...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Vinik, Yaron, Shatz-Azoulay, Hadas, Vivanti, Alessia, Hever, Navit, Levy, Yifat, Karmona, Rotem, Brumfeld, Vlad, Baraghithy, Saja, Attar-Lamdar, Malka, Boura-Halfon, Sigalit, Bab, Itai, Zick, Yehiel
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424493/
https://ncbi.nlm.nih.gov/pubmed/25955862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05914
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