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HypE-specific Nanobodies as Tools to Modulate HypE-mediated Target AMPylation

The covalent addition of mono-AMP to target proteins (AMPylation) by Fic domain-containing proteins is a poorly understood, yet highly conserved post-translational modification. Here, we describe the generation, evaluation, and application of four HypE-specific nanobodies: three that inhibit HypE-me...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Truttmann, Matthias C., Wu, Qin, Stiegeler, Sarah, Duarte, Joao N., Ingram, Jessica, Ploegh, Hidde L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424278/
https://ncbi.nlm.nih.gov/pubmed/25678711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634287
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