Notch Decoys that Selectively Block Dll/Notch or Jagged/Notch Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth

A pro-angiogenic role for Jagged-dependent activation of Notch signaling in the endothelium has yet to be described. Using proteins that encoded different NOTCH1 EGF-like repeats, we identified unique regions of DLL-class and JAG-class ligand/receptor interactions, and developed Notch decoys that fu...

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Pubblicato in:Cancer Discov
Autori principali: Kangsamaksin, Thaned, Murtomaki, Aino, Kofler, Natalie M., Cuervo, Henar, Chaudhri, Reyhaan A., Tattersall, Ian W., Rosenstiel, Paul E., Shawber, Carrie J., Kitajewski, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423829/
https://ncbi.nlm.nih.gov/pubmed/25387766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0650
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