Notch suppresses angiogenesis and progression of hepatic metastases

The Notch pathway plays multiple key roles in tumorigenesis, and its signaling components have therefore aroused great interest as targets for emerging therapies. Here we show that inhibition of Notch, using a soluble receptor Notch1 decoy, unexpectedly caused a remarkable increase in liver metastas...

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Publicat a:Cancer Res
Autors principals: Banerjee, Debarshi, Hernandez, Sonia L., Garcia, Alejandro, Kangsamaksin, Thaned, Sbiroli, Emily, Andrews, John, Forrester, Lynn Ann, Wei, Na, Kadenhe-Chiweshe, Angela, Shawber, Carrie J., Kitajewski, Jan K., Kandel, Jessica J., Yamashiro, Darrell J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401639/
https://ncbi.nlm.nih.gov/pubmed/25744722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1493
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