Guanine Nucleotide Exchange Factor αPIX Leads to Activation of the Rac 1 GTPase/Glycogen Phosphorylase Pathway in Interleukin (IL)-2-stimulated T Cells

Recently, we have reported that the active form of Rac 1 GTPase binds to the glycogen phosphorylase muscle isoform (PYGM) and modulates its enzymatic activity leading to T cell proliferation. In the lymphoid system, Rac 1 and in general other small GTPases of the Rho family participate in the signal...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Llavero, Francisco, Urzelai, Bakarne, Osinalde, Nerea, Gálvez, Patricia, Lacerda, Hadriano M., Parada, Luis A., Zugaza, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423703/
https://ncbi.nlm.nih.gov/pubmed/25694429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.608414
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