Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-suppressive Activity of Profilin-1

The actin-binding protein profilin-1 (Pfn1) inhibits tumor growth and yet is also required for cell proliferation and survival, an apparent paradox. We previously identified Ser-137 of Pfn1 as a phosphorylation site within the poly-l-proline (PLP) binding pocket. Here we confirm that Ser-137 phospho...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Diamond, Marc I., Cai, Shirong, Boudreau, Aaron, Carey, Clifton J., Lyle, Nicholas, Pappu, Rohit V., Swamidass, S. Joshua, Bissell, Mina, Piwnica-Worms, Helen, Shao, Jieya
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423694/
https://ncbi.nlm.nih.gov/pubmed/25681442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619874
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