Formation of Disulfide Bridges Drives Oligomerization, Membrane Pore Formation, and Translocation of Fibroblast Growth Factor 2 to Cell Surfaces

Fibroblast growth factor 2 (FGF2) is a key signaling molecule in tumor-induced angiogenesis. FGF2 is secreted by an unconventional secretory mechanism that involves phosphatidylinositol 4,5-bisphosphate-dependent insertion of FGF2 oligomers into the plasma membrane. This process is regulated by Tec...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Müller, Hans-Michael, Steringer, Julia P., Wegehingel, Sabine, Bleicken, Stephanie, Münster, Maximilian, Dimou, Eleni, Unger, Sebastian, Weidmann, Georg, Andreas, Helena, García-Sáez, Ana J., Wild, Klemens, Sinning, Irmgard, Nickel, Walter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Membrane Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423683/
https://ncbi.nlm.nih.gov/pubmed/25694424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.622456
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