Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

Leishmaniasis is a neglected vector-born disease caused by a protozoan of the genus Leishmania and affecting more than 1.300.000 people worldwide. The couple tryparedoxin/tryparedoxin peroxidase is essential for parasite survival in the host since it neutralizes the hydrogen peroxide produced by mac...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Brindisi, Margherita, Brogi, Simone, Relitti, Nicola, Vallone, Alessandra, Butini, Stefania, Gemma, Sandra, Novellino, Ettore, Colotti, Gianni, Angiulli, Gabriella, Di Chiaro, Francesco, Fiorillo, Annarita, Ilari, Andrea, Campiani, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423475/
https://ncbi.nlm.nih.gov/pubmed/25951439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09705
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