Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment

Tumor initiation and growth depend on its microenvironment in which cancer-associated fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and interleukin (IL)-6 signal pathways are involved in the crosstalk between tumor and stromal cells. However, how PGE2-mediated si...

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Publicado no:Cell Res
Main Authors: Li, Pu, Shan, Jing-Xuan, Chen, Xue-Hua, Zhang, Di, Su, Li-Ping, Huang, Xiu-Ying, Yu, Bei-Qin, Zhi, Qiao-Ming, Li, Cheng-Long, Wang, Ya-Qing, Tomei, Sara, Cai, Qu, Ji, Jun, Li, Jian-Fang, Chouchane, Lotfi, Yu, Ying-Yan, Sun, Fang-Zhen, Xu, Zhi-Heng, Liu, Bing-Ya, Zhu, Zheng-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423088/
https://ncbi.nlm.nih.gov/pubmed/25916550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.51
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