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Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo

The α-defensins, human neutrophil peptides (HNPs) are the predominant antimicrobial peptides of neutrophil granules. They are synthesized in promyelocytes and myelocytes as proHNPs, but only processed in promyelocytes and stored as mature HNPs in azurophil granules. Despite decades of search, the me...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Glenthøj, Andreas, Nickles, Katrin, Cowland, Jack, Borregaard, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422583/
https://ncbi.nlm.nih.gov/pubmed/25945506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125483
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