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Th1-Like ICOS(+) Foxp3(+) T(reg) Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice
Type 1 diabetes (T1D) occurs through a breakdown of self-tolerance resulting in the autoimmune destruction of the insulin producing β-islets of the pancreas. A numerical and functional waning of CD4(+)Foxp3(+) regulatory T (T(reg)) cells, prompted by a pancreatic IL-2 deficiency, accompanies Th1 aut...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4422433/ https://ncbi.nlm.nih.gov/pubmed/25946021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126311 |
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