Th1-Like ICOS(+) Foxp3(+) T(reg) Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice

Type 1 diabetes (T1D) occurs through a breakdown of self-tolerance resulting in the autoimmune destruction of the insulin producing β-islets of the pancreas. A numerical and functional waning of CD4(+)Foxp3(+) regulatory T (T(reg)) cells, prompted by a pancreatic IL-2 deficiency, accompanies Th1 aut...

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Vydáno v:PLoS One
Hlavní autoři: Kornete, Mara, Mason, Edward S., Girouard, Julien, Lafferty, Erin I., Qureshi, Salman, Piccirillo, Ciriaco A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422433/
https://ncbi.nlm.nih.gov/pubmed/25946021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126311
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