Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men

Leydig cell number and function decline as men age, and low testosterone is associated with all “Western” cardio-metabolic disorders. However, whether perturbed androgen action within the adult Leydig cell lineage predisposes individuals to this late-onset degeneration remains unknown. To address th...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: O’Hara, Laura, McInnes, Kerry, Simitsidellis, Ioannis, Morgan, Stephanie, Atanassova, Nina, Slowikowska-Hilczer, Jolanta, Kula, Krzysztof, Szarras-Czapnik, Maria, Milne, Laura, Mitchell, Rod T., Smith, Lee B.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422361/
https://ncbi.nlm.nih.gov/pubmed/25404712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-255729
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